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Tag Archives: ApoE4 and Alzheimers

Asking questions and dealing with the answers

One motivation to getting my genome sequenced was to see whether I had known risk alleles for dementia (spoiler alert: I don’t). My dad was diagnosed with frontotemporal lobe dementia a few years before he died. His brain biopsy after death returned a diagnosis of Alzheimers. He might have had both.One of the known risk alleles is ApoE4. Homozygosity for ApoE4 is a strong predictor of Alzheimers by the eighth decade. I knew I wasn’t homozygous for...

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