by I was provoked to write the post immediately below by this shocking article which suggests possible fraud. I feel the need to comment on this passage “Yet Aβ still dominates research and drug development. NIH spent about .6 billion on projects that mention amyloids in this fiscal year, about half its overall Alzheimer’s funding. Scientists who advance other potential Alzheimer’s causes, such as immune dysfunction or inflammation, complain they have been sidelined by the “amyloid mafia.” “ WTF ? It is not one or the other. Amyloid beta oligomers bind to tole-like pattern receptors on microglia causing them to release inflammatory peptides (including TNF alpa). TNF alpha stimulates the production of amyloid beta. It isn’t amyloid beta *or*
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I was provoked to write the post immediately below by this shocking article which suggests possible fraud.
I feel the need to comment on this passage
“Yet Aβ still dominates research and drug development. NIH spent about $1.6 billion on projects that mention amyloids in this fiscal year, about half its overall Alzheimer’s funding. Scientists who advance other potential Alzheimer’s causes, such as immune dysfunction or inflammation, complain they have been sidelined by the “amyloid mafia.” “
WTF ? It is not one or the other. Amyloid beta oligomers bind to tole-like pattern receptors on microglia causing them to release inflammatory peptides (including TNF alpa). TNF alpha stimulates the production of amyloid beta. It isn’t amyloid beta *or* inflammation. It’s as if the chicken researchers said that they have been sidelined by the egg mafia. The two aspects of Alzheimer’s are demonstrably linked.
It seems the assertions with no links was not well received. Here are cites