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From the frontiers of viral immunology

Summary:
Ever since the COVID mRNA vaccines (Moderna and Pfizer) proved themselves, I became convinced they are the future of viral vaccines. Looks like a polyvalent flu vaccine is in the works that may obviate annual strain-specific vaccines.“In this work, we developed a nucleoside-modified messenger RNA (mRNA)–lipid nanoparticle vaccine encoding hemagglutinin antigens from all 20 known influenza A virus subtypes and influenza B virus lineages. This multivalent vaccine elicited high levels of cross-reactive and subtype-specific antibodies in mice and ferrets that reacted to all 20 encoded antigens. Vaccination protected mice and ferrets challenged with matched and mismatched viral strains, and this protection was at least partially dependent on antibodies.

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Ever since the COVID mRNA vaccines (Moderna and Pfizer) proved themselves, I became convinced they are the future of viral vaccines. Looks like a polyvalent flu vaccine is in the works that may obviate annual strain-specific vaccines.

“In this work, we developed a nucleoside-modified messenger RNA (mRNA)–lipid nanoparticle vaccine encoding hemagglutinin antigens from all 20 known influenza A virus subtypes and influenza B virus lineages. This multivalent vaccine elicited high levels of cross-reactive and subtype-specific antibodies in mice and ferrets that reacted to all 20 encoded antigens. Vaccination protected mice and ferrets challenged with matched and mismatched viral strains, and this protection was at least partially dependent on antibodies. Our studies indicate that mRNA vaccines can provide protection against antigenically variable viruses by simultaneously inducing antibodies against multiple antigens.”

A multivalent nucleoside-modified mRNA vaccine against all known influenza virus subtypes,” Science, Authors

COVID vaccines and antibodies,” Angry Bear, Joel Eissenberg

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