Childhood stress or chronic childhood unhappiness can alter the gene expression resulting in chronic, severe, and treatment resistant forms of depression, as well as chronic mild depression, known as dythymia.People with this disorder cannot manufacture acetyl-l-carnitine properly, but amazingly, supplementing with Acetyl-l-carnitine not only relieves the depression (and often within days), it can also repair the faulty gene expression leading to a lasting cure.LAC - Acetyl-l-carnitine That LAC treatment might reverse some of the epigenetic-based vulnerability could have enormous clinical implications. In the defeat-stress model, the low BDNF in the hippocampus is related to trimethylation of H3K27 (H3K27me3) that is not reversed by traditional ADs (even though they do reverse the BDNF
Topics:
Mike Norman considers the following as important:
This could be interesting, too:
New Economics Foundation writes New Economics Podcast: Why is the benefits system failing disabled people
Michael Hudson writes Jill Stein: Splitting the Pro-Imperial Vote
Editor writes In search of radical alternatives
Stavros Mavroudeas writes «Οι καταστροφικές επιπτώσεις της ΕΕ στην Ελλάδα και τους εργαζόμενους» – Στ.Μαυρουδέας ΠΡΙΝ 20-21/4/2024
People with this disorder cannot manufacture acetyl-l-carnitine properly, but amazingly, supplementing with Acetyl-l-carnitine not only relieves the depression (and often within days), it can also repair the faulty gene expression leading to a lasting cure.
LAC - Acetyl-l-carnitine
Myriad of implications of acetyl-l-carnitine deficits in depression