The Angry Bear

Tired: Remdesivir Wired: Merimopodib Inspired: Both Merimopodib (of which I just read for the first time) is an inhibitor of an enzyme used to make Guanosine. Viruses need a lot of Guanosine (and other nucleosides) to reproduce, so it is an antiviral. It can be taken orally and there is a known safe dose. A preprint asserts that a combination of Remdesivir and Merimopodib completely blocks SARS-CoV-2 replication in vitro. Here is the abstract The IMPDH...

If you open it, they still won’t come: restaurant edition In case you haven’t already seen it, here is the OpenTable restaurant reservation data from 3 Confederate States that “reopened” their economy at the end of April: Even though restaurants were open again, reservations were still down over 80% from a year ago. This highlights an important behavioral aspect of the pandemic: people did not wait for their State governments to order lockdowns in...

How Likely Is A Second Wave Of SARS-CoV-2? Dr. Anthony Fauci has testified before a Senate committee that he is worried that there may be a serious “Second Wave” of the current SARS-CoV-2 pandemic in the United States.  The basis for this fear is the experience over a century ago with the Spanish flu, still deadlier than the current pandemic.  It came in three full waves, and of those the second was easily substantially larger than the other two.  The...

The Greater Good “If they can get you asking the wrong questions, they don’t have to worry about answers.” — Thomas Pynchon, Gravity’s Rainbow Originally written in 2018 on the Save The Post Office blog and featured at Angry Bear in 2019, retired North Carolina Post Master Mark Jamison wrote on the issues facing USPS while in competition with Amazon, UPS, and FedX. The same issue has been brought to the forefront again with President Trump refusing to...

Testing and the 52 Petri dishes of democracy Since the federal government has abandoned the field, fighting the coronavirus pandemic has been left to the States, territories, and the District of Columbia. This means that there is no unified response and instead there are 52+ individual responses. That is the biggest challenge in tracking the pandemic. Which means I’ve been looking for the best resources to show how the States are doing in comparison...

(Dan here…better late than not) by Barkley Rosser The 75th Anniversary Of VE Day: Forgettable Or Boring? My wife, Marina, as many of those reading this know, is from the Soviet Union, and takes extremely seriously the anniversary of the victory of the Soviet Union and its allies over Nazi Germany, which became official at 10:45 PM in Berlin on May 8, 1945, which was 12:15 May 9 Moscow time. So, while all of the rest of the world celebrates VE Day on May...

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What happens when you downsize a large number of people? Well, it depends on the cohort downsized. In this case, [embedded content] That’s correct; Average Hourly Earnings skyrocketed from $28.67 to $30.01: up $1.34. For context, that one-month change matches the average hourly earnings growth from September/October of 2018 until March of this year–18 months of increases in a month. And all it took was eliminating the jobs of about 6% of the U.S....

by Ken Melvin What to do About The Schools There needs to be a plan in place that deals with: grade levels, Covid Virus testing, schedules, classroom size, in-school traffic flow patterns, staffing, transportation, …  The how and when are tied together. And yes, all these are interconnected. How to safely get 3,000 high school students to and from school; from class to class; to, into and out of classrooms; to, into and out of the cafeteria; … ...